胎生期の薬理学的研究-鶏胎仔に及ぼすAtropin,Scopolamineの影響と両者の胎仔体内に於ける運命に就いて

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As part of the studies on the embryonal stage, the author investigated the influences of atropine and scopolamine on the chick embryo and their fate in the embryo. Further, the author attempted to estimate the degree of the disturbance of the organ by investigating the influences of both alkaloids on the splitting action of the chick embryo liver on protein and diglycine.<BR>Even when 5mg of atropine and scopolamine were injected, the eggs were successfully hatched. When the toxicity of atropine and scopolamine were compared in the cases where the eggs died, the results indicated that the toxicity of atropine is stronger than the other. The excretion of these two substances is extremely minute. The tendency of accumulation of these substances in the liver was observed, but it was also found to be very slight. Most part of these substances injected was considered to be splitted in the eggs or in the embryonal body. No remarkable difference in the splitting capacity of the liver of the chick embryo treated with these substances compared with that of untreated control.
昭和大学・昭和医学会の論文