抗結核剤の肝臓細網内皮系統の貧喰機能に及ぼす影響

概要

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Empolying the absorption test of lithion carmin by the Kupffer's stellate endothelial cells of mouse liver, the influences of various antituberculosis drugs on the reticuloendothelial system were investigated. When one dose calculated from the usual human dose of an antituberculosis drug (1g/50kg of SM, 2g/50kg of PAS-Na, 0.2g/50kg of INAH or 0.02g/ 50kg of TB<SUB>1</SUB>) was administered to mice, it was found that the influence exercised by PAS-Na on the reticuloendothelial system is milder compared with those by the other drugs. The other drugs were found to have activated the system approximately in a same degree. The phagocytic activity of the system was found to demonstrate a tendency of lowering the activity when administered for 5 consecutive days on the contrary. When the above doses were increased by 5 times respectively and given in one injection, the system was generally activated, although the influence by INAH was found milder than others. When the same dose was administered for 5 consecutive days, the activity in many cases were found lowered although TB<SUB>1</SUB> activated in a fair degree. Further, when SM combined with other 3 drugs was given in one dose, or when a large dose exceeding its lethal dose was given in one dose, activation was recognized.
学校法人昭和大学・昭和医学会の論文