灌腸に関する研究-V.B1塩酸塩TPD並びにPASの大腸内吸収に就て

概要

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Previously, Muto, Honda and others conducted experiments on the absorption of vitamin B1 hydrochloride and TPD in the large intestine, and recognized that the amount of these substances absorbed were quite small when they were administered alone as enema. Further, Sekiya performed experiments on the absorption of PAS in the large intestine, and reported that almost no absorption was recognized when PAS alone was administered as enema. In the present paper, the authors investigated as to how the absorption of vitamin B1 hydrochloride, TPD and PAS in the large intestine is affected by those absorption promoting substances, which were hitherto taken up in the authors' Department. The followings are the conclusions briefly summarized. 1) Simple combination of PAS with vitamin B, hydrochloride or with TPD did not promote the absorption. 2) The absorption was remarkably promoted in every cases when the combination of PAS with vitamin B1 hydrochloride or with TPD further combined with cattle bile, glycocoll, histidine, calcium chloride or with glucose. Histidine demonstrated specifically favorable absorption. 3) When administered as enema, either alone or in combination, the amount of. vitamin B1 absorbed in the case of TPD was found larger compared with that in the case of vitamin B1 hydrochloride.
学校法人昭和大学・昭和医学会の論文