灌腸に関する研究
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Following the investigations in the absorption of aminoacids in the colon, the authors conducted investigations in the absorption of polytamin, which is a mixture of various aminoacids produced by the splitting of protein, and peptone, which is a mixture of various polypeptides, in the colon.<BR>When 5% polytamin was administered as enema in combination with 10% and 20% glucose, almost no changes were recognized in the A-N content and R-N content, indicating that polytamin was not absorbed in this case. Even in the case when cattle bile was combined in addition to glucose, polytamin was not absorbed. When polytamin was administered as enema in combination with glucose, calcium chloride and cattle bile, the A-N content and R-N content were found increased, and the increment was larger than that in the case of the administration of glucose, calcium chloride and cattle bile without polytamin, indicating that polytamin was absorbed to certain extent in this case. Furthermore, in either of the cases with and without polytamin, the serum calcium content was found increased up to more than 15 mg/dl 15 minutes after the administration, and the rabbits were demonstrating a severe intoxication symptoms. When the concentration of calcium chloride was made to 0.5% in the same combination, almost no absorption of polytamin was recognized. Simultaneously, the increment in the serum calcium content and the intoxication symptoms were found very slight. Polytamin was not absorbed when administered in combination with Sprase alone or with Sprase and glucose.<BR>In his previous report, Misu recognized that glycocoll or taurin is not absorbed when each of them alone is administered as 5 solution, but, when they are administered in combination with 20% solution of glucose, a fair amount of them is absorbed, and that, in combination with glucose, calcium chloride and cattle bile, a large amount is absorbed. In the case of polytamin, however, it is not absorbed, as stated in the above, with the combination of glucose, and it is absorbed only when administered in combination with glucose, calcium chloride and cattle bile, though the amount absorbed is much smaller compared with that in the cases of glycocoll or taurin.<BR>In the case of peptone, it was not absorbed when it was administered alone as enema as 5% solution. Even when peptone was administered in combination with calcium chloride, it was not absorbed though calcium chloride was absorbed. Even when peptone was administered in combination with glucose, calcium chloride and cattle bile, peptone was found not to be absorbed with no remarkable differences in A-N and R-N contents, serum calcium content or in the severity of the intoxication symptoms in the rabbits from those in the cases of the administration of glucose, calcium chloride and cattle bile without peptone. In other words, no absorption of peptone was recognized in these experiments.<BR>In short, as far as the present experiments are concerned, the combination with calcium chloride and cattle bile, specifically a fair amount of calcium chloride, is necessary for the absorption of polytamin in the colon. Consequently, sever intoxications induced by abnormal absorption of calcium and bile were observed among the rabbits employed, thereby 2 rabbits became fatal. The occurrence of this intoxication was similar to those reported by Hitomoto, Kato and others of the Department.
- 昭和大学・昭和医学会の論文