蛋白同化ホルモンの副腎皮質ホルモンに対する拮抗作用 鶏胎仔の骨発育に関する実験的研究
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概要
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The antagonistic effects of anabolic steroid (oxymethenolone) to adrenocortical hormone (hydrocortisone acetate) in the proximal cartilaginous end of tibia of the eighteenth day chick embryo were studied by administering both hormones simultaneously to the seventh day chick embryo of incubation.<BR>The results are summarized as follows:<BR>1) Dwarfism due to adrenocortical hormone is improved by administering an adequate amount of anabolic steroid. Death rate, lenth of tibia, and body weight is also improved.<BR>2) The growth of the epiphyseal cartilage of long bones is parallel to the length of long bones.<BR>3) An enlargement of a medullary cavity, an improvement in the clearness of boudaries between cartilaginous zones, an increase in the regularity of the arrangements of columnar cartilaginous cells and an appearance of osteoblasts are recognized histologically.<BR>4) In sections stained with PAS, a marked increase in glycogen is found in the matrix of resting cartilaginous zone of the combined administrations group.<BR>5) In sections stained with alcian ble and toluidine blue, increase in acid mucopolysaccharide is found in the matrix of the columnar cartilaginous zone and the calcifing cartilaginous zone of the combined administration group compared with the adrenocortical hormone group.<BR>6) By means of alkaline phosphatase staining, the combined administration group has the same amount increase in alkaline phosphatase as the control group.<BR>7) The above facts show that an adequate amount of anabolic steroid reacts antagonistically to adrenocortical hormone and it also improve environments for ossification.
- 学校法人 昭和大学・昭和医学会の論文