Vitamin B1及びSB1の薬理作用-B1並にその誘導体のAcetylcholin,Adrenalin作用に及ぼす影響に就て-
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概要
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In the present paper, the results of a comparative investigations on the influences of vitamin B<SUB>1</SUB> and SB<SUB>1</SUB> etc. on the activity of acetylcholin and adrenalin are reported.<BR>The activity of acetylcholin is enhanced by vitamin B<SUB>1</SUB> at the dosis of 2 mg per kg or more. In the case of vitamin SB<SUB>1</SUB>, the activity is enhanced even at the dosis of 1 mg per kg. Aethyl-B<SUB>2</SUB> enhances the activity of acetyl-cholin at the dosis of 0.5 mg per kg to such an extent that it influences the heart, blood pressure and respiration. However, generally speaking, the activity of vitamin SB<SUB>1</SUB> is the most intense. In the case of co-carboxylase, the activity is found to be inconsistent.<BR>Aethyl-B<SUB>1</SUB> enhances the activity of adrenalin, while co-carboxylase affected inhibitory.<BR>In all cases, the enhancement of the activity of acetylcholin, enhancement or inhibition of the activity of adrenalin are most remarkably noticed when vitamin B<SUB>1</SUB> and its derivatives are applied simultaneously in combination of acetylcholin or adrenalin.
- 学校法人 昭和大学・昭和医学会の論文