産科領域における焦性ブドー酸およびα-ケトグルタル酸に関する研究

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The present work was done in order to examine the metabolism in pregnants, especially in those suffering from gestational toxicosis, and the influence of puerperal work on it, and in addition, to study its effect on fetus.<BR>The blood levels of pyruvic acid and α-ketoglutaric acid were determined simultaneously by enzymological methods with the following results.<BR>The blood levels of pyruvic acid and α-ketoglutaric acid were 0.559±0.038 and 0.163±0.005 mg/dl in healthy non-pregnants. They were both higher in pregnants. The pyruvic acid level was slightly higher at delivery than during pregnancy, but the α-ketoglutaric acid level did not change at delivery. They showed almost the same levels in normal delivery, bruch extraction and clamp delivery. Both levels returned nearly to the range of healthy non-pregnant women about a month after childbirth. They were both higher in the women with severe lochia, but the α-ketoglutaric acid level was slightly lower in those with slight lochia.<BR>Both pyruviate and α-ketoglutarate levels were high in the pregnants with severe gestational toxicosis. They remained high during childbed in the women with severe gestational toxicosis in whom they had been high. They were lower in umbilical blood than in mother's. They did not vary with the time needed for delivery and the severity of hemorrhage.
学校法人昭和大学・昭和医学会の論文