眼球突出症に関連する家兎の眠窩周辺緒組織の病理学的検討
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In the present experiment, Saponin was injected intramusculary into rabbits twice weekly at a concentration of 1, 4, and 8mg/kg, respectively.<BR>The maximum number of injections reached 117 times, and they were divided into 3 groups of short, middle and long term administration. Studies on the changes of the surrouding soft tissue of the optic funicle in the orbit to reveal the following results were then carried out.<BR>1) On both lobes of Harder's gland, there were observed atrophy, irregular arrangement, colliquative change and crumbling of epithelia of epithelia of the gland in the group of short term as a fundamental findings. Degeneration, dissociation, thyloida-change, fusion and enlargement of ducts became remarkable with the increase of dosage.<BR>2) We have seen atrophy of epithelia of excretory duct, but there was no relation between the dosage and administrating term.<BR>3) Hyperemia in interstitium of Harder's gland was common finding, and there was rarefaction of tissue in a slight degree receiving a large quantity and above medium quantity.<BR>4) As to edema of the surrounding soft tissue of the optic funicle in the orbit, it appeared slightly in all cases, except 4 cases in those receiving 1mg/kg. A remarkable edema of muscle (short term group), and of nerve tissue (middle term group) was found in one case each. It was observed slightly in all cases in the middle and long term group in those receiving 4mg/kg, and in all cases of every group in those receiving 8mg/kg. In the long term group transitional figures to fibrosis from edema were frequently.<BR>5) It is assumed that the thyroidal changes of glandular lumen of the superior lobe indicate hyperfunctional condition, and fusion, enlargement and narrowing of ducts show hypofunctional condition.<BR>6) Edema occured in the surrounding soft tissue of optic funicle in orbit containing nerve and muscle tissue in every group, and edema with rarefaction of interstitium of Harder's gland situated in the posterio-lateral wall work together and cause of exophthalmus.
- 学校法人 昭和大学・昭和医学会の論文