化学的物質投与による肺臓所見の検討

概要

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In the present experiment, Saponin solution was administrated subcutaneously to rats twice a week in different doses of 1 mg, 4 mgs and 8 mgs per kg. Then hematological examination and histopathological investigation were made on the changes in the lungs dividing the animals into three groups according to survival period.<BR>Hematological findings showed progressive drops in both red blood cells and hemoglo-bin, after administration of the solution, and increase in the number of reticulocytes.<BR>Histopathologically the group given the small amount of the solution shows the changes which referred to vital reaction related to dilatation and incomplete expansion of alveoli, swelling and edema of alveolar septum, and infiltration of round cells, and the group given the large amount mainly shows the changes of disturbance of the circulation, which become more distinct in proportion to the quantity and the period of medication. Furthermore qualitative changes are manifested as swelling and degeneration of the vessels followed by fibrous hypertrophy and fibrosis around vessels. These changes are based on hypoxia by action of Saponin solution. Therefore it is considered for uniqueness of the lung structure that the changes are concentrated in alveolar septum.<BR>It is assumed that these changes suggest a tendency to proceed toward fibroscrelosis, according to prologation of the time elapsed.
学校法人昭和大学・昭和医学会の論文