カドミウムを作用した鶏胎仔の脛骨の病理組織学的変化について

概要

論文の詳細を見る
The 18 th day embryos, in which were administerd the solution of 1, 10, 50γ cadmium at 5 th embryo days, were killed and the studied mainly histologically on the end of tibia and kidney. Protein and glucose in allantoic fluid of these embryos were analysed quontativelly be paper-chromatograph. The results are summarized as follows : 1) By microradiography and tetracline labelling, delay of enchondrale ossification at the end of tibia was found in direct proportion to increase dose of adminstered cadmium. 2) On histological, the extent of the cartilage zone and the density of their caltilage cells decreased in inversaly proportional to dose of cadmium and at the same time were seen the degenerative swelling of the cell and irreguality of the cell arrangment in columnar zone. 3) A few decreasing of the glycogen in the stationary cartilage zone were recognized by PAS staning in the cadmium adminsted groups. 4) A few decreasing of mucopolysaccharide in stationary and columnar cartilages were seen by Alcian blue and Toluidine blue staining. 5) It was seen on the cadmium administerd groups that the eminent vacuolar and granular degeneration of the renal tubule and falling of the epithel cells into renal tubule. 6) In the allantoic fluid, the contens of protain and glucose were ditected propotionary with dose of administerd cadmium.
昭和大学・昭和医学会の論文