肝臓壊死に関する実験病理学的研究

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In the present experiment, rabbits were divided into four groups (i. e. group A, B, C and D) to receive saponin at four graded dosage levels, 0, 1, 4, or 8 mg per kg of body weight daily. Each dosage group was subdivided in to acute group given the toxic substance for less than fifty days and chronic group receiving it for more than sixty days. Then pathologic histological study on the liver was carried out. Results 1) In rabbits in the acute groups, zonal necrosis of hepatic cells showed the highest incidence in the midlobular region, followed, in order, by the centrilobular area and the perilobular region. 2) In the chronic dosage groups, on the other hand, necrosis of liver cells was noted to be most frequently centrilobular and lowest in incidence in the perilobular region as in the acute dosage group. 3) Such localized expressions of intralobular histopathologic changes as vacuolar degeneration, granular degeneration of liver cells, capillary hyperemia and dilatation, dilated bile ducts and so forth, were noted to be most frequent in the centrilobular region of the liver of animals that had received the highest doses both acute and chronic dosage groups. These microscopic findings are precursory to hepatic necrotization and, as may be pointed out from the hematological and pathomorphological standpoints, are strongly suggestive of hypoxiac nature of the toxicologic responsa.
昭和大学・昭和医学会の論文