気管支喘息と感染に関する研究 ウイルスとワクチン療法
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概要
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To elucidate the role of upper respiratory virus to bronchial asthma, the studies on anti-adeno virus 3 antibody titer and anti-parainfluenza virus titer were carried out with the 210 cases of bronchial asthma and 21 cases of normal subjects by means of complement fixation test and HI test. Anti-influenza virus titer were carried out with 12 cases of bronchial asthem by means of HI test.<BR>The results were as follows;<BR>1) Anti-adeno viral titer of the patients with bronchial asthma showed to be higher than that of normal subjects (p<0.01) . Also anti-para influenza viral titer was significant difference between former and later (p<0.01) .<BR>2) The titer of the asthma patients of infectious types or mixed types was higher than that of atopic types.<BR>3) In winter, anti-viral titer showed to be higher, and correlated to the predisponsing season of the upper respiratory viral infection.<BR>4) There is no statistical difference between steroid-receiving patients and no steroid in anti-viral titer. IgE globulin levels showed to be high in atopic types compared to the other types.<BR>5) In generally, clinical states in bronchical asthma were tendency to improve, accompanied with increasing serum anti-viral titer by vaccination therapy in gradual increase of dosage.<BR>6) In 79 percent of the patients were effective in influenza vaccination therapy.<BR>7) The mechanism of inflenza vaccination treatment was suggested, to act the hyposensitizing effects as well as the protect their infection.
- 学校法人 昭和大学・昭和医学会の論文