小児白血病におけるErythropoietinの消長

概要

論文の詳細を見る
The erythropoietion (ESF) activity in urine from children with leukemia was studied using bioassay method utilizing starved rats. One hundred twenty one specimens of urine and 15 speciments of sera obtained from 9 patients with acute myeloid leukemia, 4 with acute lymphtic leukemia and 1 with chronic myeloid leukemia, were the subjects in this study. Following results were obtained : 1. In all cases reciprocal relationship was found between hemoglobin concentration and ESF levels. In some out of patients who showed hemoglobin level at below 9 g/dl and in all patients at below 5 g/dl, a rise in ESF activity was observed. 2. The reverse mutual relationship was observed between reticulocyte-counts in peripheral blood and ESF level in urine. 3. The reverse mutual relationship was also observed between counts of nucleted red cells in bone marrow and ESF level in urine. 4. Sera from adult and leukemic children were mixed with 2 kinds of urine in leu-kemic patients whose ESF level were normal and elevated. In all cases, no significant changes in ESF activity in urine were observed by addition of sera.
学校法人昭和大学・昭和医学会の論文