Ehrlich腹水癌細胞における免疫学的研究:―リンパ球と癌免疫―
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概要
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Immunological studies were made on Ehrlich ascites cancer. Results were as follow:<BR>1) The mice sensitized with Ehrlich ascites cancer extract with Incomplete or Complete Freund's Adjuvant, were shown to survive a little longer than those sensitize with same antigen without adjuvant.<BR>2) By means of fluorescent antigen technique, specific stainings were found in the menbrane of splenic lymphocytes of immunized animals, the fluoresence rate was highest on the 7 th day after immunization.<BR>3) Adoptive immunity was established by transfer of the immunized splenic cells into peritoneal carity of normal mice, and survival effect of the immunized cells was recognized untill 7 th day. Thus the presence of cellular antibody was suggested.<BR>4) Immunized splenic cells adhered to Ehrlich cells, and the rate of adherence was highest on the 7 th day of immunity.<BR>5) Blastoid transformation of lymphocytes by phytohemagglutinin and Ehrlich ascites cancer extract occured more markedly in the mice of immunized group than those of control group, and it was highest on the third day of immunity.<BR>It was suggested that the immunity ageinst Ehrlich ascites cancer was mostly related to cellular antibodies.
- 昭和大学・昭和医学会の論文