肝障害における骨髄DNAおよび肝機能に対する二・三の肝庇護剤の効果について

概要

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That the bone marrow gets purine from liver has been claimed by Lajtha. 2-mercap-topropionyl-glycine (MPG), containing SH in the molecule is expected to protect the liver from radiation damage given prior to liver irradiation. However, that liver disorders of various kinds have been ameliorated by MPG has a good reason the drug to ameliorate radiation-induced liver disorder though given after irradiation.<BR>Some experiments were carried out and following results were obtained. Decreased DNA synthetic rate in bone marrow and prolonged BSP clearance rate after liver irradiation were improved by MPG administration.
昭和大学・昭和医学会の論文