Vitamin B1およびその関連物質の中枢ならびに末梢神経に及ぼす影響
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概要
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Pharmacodynamic properties of thiamine (B<SUB>1</SUB>) and its related substances were studied in the central and the peripheral nervous system. The results were as follows:<BR>1. The following vasomotor actions were shown when these substances were administered intravenously to the rat: depression with 5 to 20 mg/kg of B<SUB>1</SUB>, elevation with 5 mg/kg of oxythiamine, heteropyrithiamine, o, s-dicarbethoxythiamine, depression followed by elevation with 10 to 20 mg/kg of those three mentioned above, elevation with 5 to 10 mg/kg of thiamine tetrahydrofurfuryl disulfide, and depression with 20 mg/kg of the same. These vasomotor actions were similar to that observed in the rabbit.<BR>2. By intraventricular injection of Bl and its relatives to the rat with the dose of 50 to 200 μg/animal, a long lasting blood pressure elevation was observed in every case.<BR>3. This effect of blood pressure elevation caused by the intraventricular injection of B<SUB>1</SUB> and the related was inhibited by the pre-treatment with 20 μg of anti-histaminic into the ventricule.<BR>4. The direct cause of the death induced by the subcutaneous administration of Bl and the related is supposed to be the paralysis of the respiratory muscle by the neuromuscular junction blocking.<BR>5. The toxicity of B<SUB>1</SUB> antagonist is not related to the potency of antagonistic action.<BR>6. Intoxicated symptoms observed by the injection of B1 and the related into the ventricule were quite different from that observed by the subcutaneous injection.<BR>7. The seizure and the death caused by the injection of B<SUB>1</SUB> and the related into the ventricule were not prevented by pyridoxal phosphate and amino-oxyacetic acid.<BR>8. The similar effects were observed with B<SUB>1</SUB> and the relatives to the action with quaternary ammonium compounds.<BR>9. The behavior and EEG observed in the adult fowl administered subcutaneously with B1 and the related were the same with those of d-tubocurarine. That is, though anesthetic-like symptom was observed, no effect on EEG was noticed.<BR>10. As to the effect observed by subcutaneous injection of B<SUB>1</SUB> and the related to chicken, whose blood-brain-barrier is incomplete, peripheral action followed by central stimulant action was observed.<BR>11. 5-hydroxytryptamine content in the brain of the chicken that presented anesthetized symptoms by the injection of B<SUB>1</SUB> and the related, was affected.
- 学校法人 昭和大学・昭和医学会の論文