脳下垂体抽出物質の死後の活性度と子宮動脈の血流に及ぼす影響について

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The method to measure FSH (follicle stimulating hormone) which is one kind of hypophysis hormone can be classified roughly into the following three, the bioassay, the immunoassay and the radioimmunoassay. Based on the Igarashi-McCann method, the author, using the male hypophysis, studied post mortem changes which take place in the FSH activity after elapse of time and temperature. Further, in order to study the effect of the hypophysis hormone on the blood flow of the generative organ, he injected the pituitary bodies extract to the rabbits, and by experimenting on the uterine artery with the use of electromagnetic flowmeter, he arrived at the following conclusion: 1) The activity of human FSH within 20 hours after death, when preserved at a temperature of 5°C, hardly changed during a month's time; when preserved at 18°C, the activity continued for 4 days; at 30°C, it died out on the 4 th day; at 37°C, it died out on the first day. 2) It is said that the FSH concentration in the blood increases in women after the climacterium period. The FSH concentration in the hypophysis extracted from the dead bodies also increased. This shows that the activity differs in the males and the females. 3) In the cases of the rabbits, hardly any change was observed in the uterine weight in spite of having injected human hypophysis extract. Howerver, the blood flow of the uterine artery increased the same as when HCG 1000 unit was injected, showing the contrasts of twofold value. 4) In the cases of the untreated pregnant rabbits, there was a two to sevenfold increase in the blood flow as compared with narmal rabbit.
学校法人昭和大学・昭和医学会の論文

脳下垂体抽出物質の死後の活性度と子宮動脈の血流に及ぼす影響について

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