クロラムフェニコール抗体に関する実験及び臨床的研究

概要

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To elucidate the mechanism of drug hypersensitivities, the studies on antibody specific for chloramphenicol (Cp) and on immunological lesions of cells and tissues were made on 300 cases with the past history of Cp receiving and rabbits sensitized with Cp azo-conjugated BSA or RSA, by means of the Passive haemagglutination test (PHA), in vitro lysis of blood leucocytes and Fluoresceint technique. The results obtained were as follows; 1) In human, PHA titer proved positive in 9.4 per cent of 300 cases with the past history of Cp receiving, especially high positive in patients of allergic disorders or collagen diseases. In rabbits sensitized with Cp, anti-Cp antibodies were almost positive, especially markedly high titer in rabbits with Cp-BSA or Cp-RSA intradermaly. 2) Fluoresceint technique showed high positive of subjects in humans and rabbits received Cp, the specific staining was observed mainly in cytoplasma of polymorph nuclear cells and lymphcyte. In human, fluoresceint positive rate was statistically corelated with that of PAH or in vitro lysis of blood leucocytes. 3) In rabbits bone marrow, erythroblastic cells remarkable decreased wheras granular cells few decrease, lymphcytes were somewhat relative increased. In peripheral blood bilds there were no abnormal findings.
学校法人昭和大学・昭和医学会の論文