カリクレイン吸入による気道アレルギ-
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概要
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Kallikrein, first extracted from human urine by Frey et al. in 1925, is now widely prescribed as a hypotensive agent. It is a kind of mucoprotein originated from animal tissue, and certain allergic diseases may be caused by inhalation or contact with Kallikrein.The clinical course and immunological tests carried out on three patients with an occupationally related allergy induced by inhalation of Kallikrein are reported. All were employed in the same chemical factory which was producing Kallikrein.Case 1- a 42 year-old housewife with nasal allergy.This patient had often suffered from congelation urticaria, and visited our clinic complaining of nasal allergy. Three months later the first attack of bronchial asthma occurred following dense exposure to Kallikrein for three months. She retired and is in good health without any complaints.Case 2-a 28 year-old unmarried woman with bronchial asthma.This patient had often had contact dermatitis after using certain soaps and cosmetics. The first attack of bronchial asthma occurred 9 months after she started working with Kallikrein capsules. Although her position was changed from the capsule making division to the tablet making division, slight symptoms are still evident.Case 3- a 57 year-old man with bronchial asthma.After dense exposure to Kallikrein for 6 months, serious attacks of bronchial asthma frequently occurred. After retiring he is in good health with no complaints.Both in cases 1 and 2, the laboratory examination revealed a remarkable eosinophilia in the peripheral blood and in the nasal smear. Levels of serum IgE. were normal. The intracutaneous test, the nasal provocative test, and Prausnitz-Küstner's passive transfer test showed respectively positive reactions in all cases. Case histories and laboratory data indicate that these three cases are those of an occupational allergy induced by inhalation of Kallikrein.
- 耳鼻咽喉科臨床学会の論文