マウス嗅上皮の発生に関する電子顕微鏡的研究 (原田康夫教授開講3周年記念論文集<特集>)
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概要
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The morphological development of the olfactory mucosa in the mouse during embryogenesis from day 10.5 of embryonic age (vaginal plug=day 0) to birth, and in the postnatal period from birth up to 2 weeks was studied using the scanning electron microscope (SEM). The SEM findings were also compared with light and transmission microscopic findings. The observed chronological changes are summarized as follows:1. The early development changes appear at day 10.5 to 11.5 of embryonic age (EA). The definite olfactory pits are formed at this stage. The surface at the bottom of the pits is covered with cells with numerous microvilli. There is a considerable number of cilia among these microvilli.2. The rudiments of the olfactory vesicle, in the form of spherical process with a few cilia, appear on the postero-lateral wall of the nasal cavity at day 12.5 EA.3. The fairly developed olfactory vesicles and the olfactory cilia are recognizable among these rudiments at day 15.5 EA. The supporting cells around the olfactory vesicle can be identified by this stage. They are densely covered with long microvilli. The basal cells can also be differentiated. At a lower magnification, a border between the olfactory part and the respiratory part is apparent. However, a higher magnification shows considerable intermingling of immature respiratory cells and olfactory cells.5. During the neonatal period the olfactory cilia further increase their number and also change their shape. Swelling and plates begin to appear at the distal ends of the cilia, and nodules are formed at their middle portions.6. The morphology of the mucosal surface at 2 weeks after birth is almost identical with that of the adult mouse.
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