Effects of Flunisolide (RS-3999) Nasal Spray on Nasal Hypersensitivity in Long-term Repetitive Administration
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The efficacy and safety of flunisolide nasal spray were investigated in long-term repetitive administration in 20 patients with nasal hypersensitivities such as nasal allergy and vasomotor rhinitis.Flunisolide nasal spray was administered in doses of 200μg/day of flunisolide in 2 puffs to each nostril 2 times every day for 7 to 77 weeks which was the longest administration. When the overall improvement was assessed after 6 weeks of administration, an improvement of 'improved or better' was found in all patients. No suppressive effect of the adrenal was found in the results for serum cortisol levels and rapid ACTH test before and after administration. No differences were found in clinical laboratory test values before and after administration, and in all patients where it was possible to conduct a fungi culture test on nasal discharge, the test results were negative.From the results of this study, flunisolide nasal spray was evaluated to be very useful.
- 耳鼻咽喉科臨床学会の論文
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- Effects of Flunisolide (RS-3999) Nasal Spray on Nasal Hypersensitivity in Long-term Repetitive Administration
- 静岡県伊東市における樹木の花粉飛散状況