反復性中耳炎とワクチン予防の可能性

概要

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Some children are subject to recurrent episodes of otitis media. At least 45% of children have three or more episodes by three years of age and up to 16% experience six or more episodes. Nontypable H. influenzae is frequently associated with recurrent and chronic episodes of middle ear disease. Infection with nontypable H. inluenzae results in strain specific immunity. Protective antibodies are directed against several outer membrane proteins of the organism. One specific protein, P6 is highly conserved among strains, antigenically stable, and has been proposed as a possible candidate for vaccine formulation.The present paper introduces a study of the immune response to P6 in the general population and in children with recurrent otitis media due to nontypable H. influenzae, and it compares the immune response to P6 in otitis-prone and normal children. The author also mentions to several vaccines for the prevention of otitis media.
耳鼻咽喉科臨床学会の論文