EBウイルスによる細胞の癌化機構について--文献的考察
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概要
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Epstein-Barr Virus (EBV) is associated with a number of lymphoid malignancies. However, the malignancy showing the most consistent association with the virus is undifferentiated Nasopharyngeal Carcinoma (NPC).Underlying the viral involvement in these EBV-associated diseases appears to be the capacity of EBV to transform the growth of human B cells, a phenomenon most easily studied in vitro where experimental infection of resting B lymphocytes leads to cellular activation and to the growth of permanently virus-transformed lymphoblastoid cell lines.EBV not only induces growth transformation of human B lymphocytes, but has more recently been shown to enhance B cell survival under suboptimal conditions in which growth is inhibited.The interplay between EBV infection and expression of cellular genes has important implications for the pathogenesis of virus-associated malignant disease. We are now studying the possible involvement of FcERII/CD23 and ADF in the enhancement of cell survival under suboptimal conditions.
- 耳鼻咽喉科臨床学会の論文