OK-432/fibrinogenの頭頚部癌局注療法

概要

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We studied the antitumor effect of intratumoral injections of OK-432 mixed with fibrinogen, including factor-XIII, and 1ml of aprotinin on head and neck carcinoma. Out of 10 patients, macroscopic evidences of reduction of tumor size were observed in two cases. The other 8 showed histopatholgical degeneration of tumor cells and marked infiltration of inflammatory cells in the area of injection. These findings suggest that OK-432 in conjunction with fibrinogen solution may play a role in the immunotherapy of head and neck carcinoma.
耳鼻咽喉科臨床学会の論文