Inner Ear Immunology and Changes of Charge Barrier. 2). Electronmicoscropic Observation of Immunized Localization.:-2) Electronmicroscopic Observation of Immunized Localization-

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We investigated the effect of inner ear immune responses on the anionicsites of the charge barrier. Guinea pigs were immunized with type II collagen (BIIn), keyhole limpet hemocyanine (KLH) o horse radish peroxidase (HRP) through the stylomastoid foramen to induce a second immune response.Polyethyleneimine (PEI) was used as a cation tracer. A decrease of the charge in the stria vascularis and endolymphatic sac was found in animals immunized with type II collagen and HRP. The KLH group did not show any of changes because the immune reaction was less due to its high molecular weight and strong negative surface charge.A decrease of the charge under immunological conditions may induce hyperpermeability of the vessels and disturb endolymph absorption, thus causing endolymphatic hydrops.
耳鼻咽喉科臨床学会の論文