小児副鼻腔炎に対するCFIXの臨床効果

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Seventy-nine children with sinusitis, seen at our hospital between December 1990 and July 1991, were treated with cefixime (CFIX) in a daily dose of 10 mg/kg (given in two divided doses). The clinical effect inveness of this therapy was assessed.1. The following 95 bacterial strains were detected; 36 strains (37.9%) of S. pneumoniae, 23 strains (24.2%) of Haemophilus (including H. influenzae), 17 strains (17.9%) of Neisseria, and 8 strains (8.4%) of M. (B.) catarrhalis.2. The overall clinical effectiveness recorded charge was 82.3%, while that determined by objective evidence of improvement3. The corresponding figures were 91.2% and 97.1% for patients with those with acute sinusitis 65.2% and 78.3% for those with chronic sinusitis, and 86.4% and 86.4% for acute exacerbations of chronic sinusitis.4. Effectiveness according to the causative bacteria was 77.8% for S. pneumoniae. 87.5% for Haemophilus, and 100% for M. (B.) catarrhalis. CFIX was also very effective against several other bacterial infections (95.8%).5. The only adverse reaction was soft stool in one of the 79 patients.It was concluded that a daily dose of 10 mg/kg of CFIX is safe and very effective.
耳鼻咽喉科臨床学会の論文