トラニラストの滲出性中耳炎に対する効果--中耳貯留液プロスタグランジン量の測定

概要

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The efficacy of tranilast, an antiallergy agent, in treating otitis media with effusion (OME) was examined by analyzing its effect on prostaglandin synthesis. In 54 patients with OME (54 ears), tranilast was administered for 14 days after elimination of middle ear effusion with tympanotomy. Forty-four ears showed no recurrence of effusion after tranilast therapy, while 10 ears developed effusion again. In these 10 ears, the levels of two prostaglandins (TXB2 and PGD2) in middle ear effusion were higher after tranilast therapy than before tranilast therapy, which suggested that prostaglandins are associated with intractable OME. The administered tranilast was transferred into the middle ear effusion effectively.
耳鼻咽喉科臨床学会の論文