Cis-platinum, peplomycin, and adriamycin chemotherapy for squamous cell carcinoma of the head and neck.

概要

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Forty-three patients with squamous cell carcinomas of the head and neck, who had received no previous treatment, were given combination chemotherapy composed of Cis-platinum (CDDP), Peplomycin (PEP), Adriamycin (ADM) intraarterially or intravenously. Complete remissions were obtained in fifteen (34.9%) and partial remissions in eighteen (41.8%). The intraarterial route was more effective than the intravenous route. The main side-effects were nausea and vomiting (83.7%), anemia (48.5%), leukopenia (69.8%), thrombocytopenia (20.9%), renal toxicity (18.6%), alopecia (65.1%), and hearing loss (30.2%). All side effects were, however, mild and transient. Combination chemotherapy composed of CDDP, PEP, and ADM appeared to be effective for squamous cell carcinoma of the head and neck. Further study should be performed on infusing and effective regional doses of drugs based on the cell kinetics, reciprocal actions of drugs, etc.
耳鼻咽喉科臨床学会の論文