Distribution of 99mTc in human nasal cavity after use of flunisolide nasal spray.

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Technetium phytate was administered intranasally by Flunisolide nasal spray, and its distribution and deposition were measured.Volunteers were divided into three groups: Nasal spray during inspiration in normal subjects, during breath holding in normal subjects and during inspiration in patients with nasal obstruction.Furthermore, in normal subjects during inspiration, the distribution was compared immediately and 20 minutes after use of the spray. (1) Influence of breathing and nasal obstruction.1. Considerable individual variation in the amount of deposited technetium was detected in all groups.2. The total amount of deposited technetium was largest in the normal inspiration group, followed by the normal breath holding group and the nasal obstruction group.3. Almost no difference in the amount of deposition was detected among the three groups in the three nasal regions. (2) Distribution change with time1. Immediately after the spray, 80% of radioactivity was detected in the anterior half of the nasal cavity, 19% in the posterior half, and 1% in the pharynx.2. At 20 min after the spray, the sum total of radio-activity in the nasal cavity, pharynx and chest through abdomen was 90% of the initial radioactivity. Ten percent could not be located. The anterior half showed 48%, the posterior half 9%, the pharynx 19%, and the chest and abdomen 14%.
耳鼻咽喉科臨床学会の論文