Effects of autonomotropic drugs on allergic nasal mucosa.

概要

論文の詳細を見る
The purpose of the present study was to elucidate the effects of different kinds of autonomotropic drugs on the nasal mucosa and on the nasal provocation reaction to specific allergens in patients with nasal allergy.1) Phenylephrine (α-agonist), phentolamine (α-antagonist), isoproterenol (β-agonist) propranolol (β-antagonist), methacholine (choline agonist) or ipratropium (choline antagonist) was applied to the nasal mucosa with an atomizer. Saline was used as a control.Denfinitive effects occurred after α-agonist and choline agonist spraying. Phenylephrine reduced the nasal airway resistance, and methacholine increased the amount of nasal secretion.2) After pretreatment with the drugs, nasal provocations were performed. The statistically significant effects were: phenylephrine spray inhibited the increase of nasal airway resistance while phentolamine and isoproterenol enhanced it; and methacholine enhanced nasal secretion, while ipratropium inhibited it. None of the drugs, however, had any effect on the number of sneezes.The present results suggest that adrenergic receptors are distributed mainly on the vessel walls and cholinergic receptors mainly on the secretory glands. Local autonomic nervous conditions affect the nasal response in different ways under different conditions.
耳鼻咽喉科臨床学会の論文