Bleo-VEMF′HA同調化学療法変法の効果--頭頚部悪性腫瘍7例についての自験 (京都大学医学部耳鼻咽喉科学教室6年間の歩み(1977-1982年)--檜学教授還暦によせて)

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Bleo-VEMF'HA synchronized chemotherapy has already been used for head and neck cancer with very effective response. The result is reported to be that the total response rate in terms of Karnofsky' evaluation is 93% and over-50% reduction rate of tumor size is 47%.However, Endoxan in this combined regimen does not immediately become highly concentrated in the cancer cells because of the masked compound type. Because of this, Carbazilquinon was used to replace Endoxan in this modified Bleo-VEMF'HA synchronized chemotherapy. This new chemotherapy for head and neck cancer produces an 86% effective rate in terms of Karnofsky' evaluation and all of the seven patients (100%) had over-50% reduction. Epipharyngeal cancer which is poorly radiosensitive or radioinsensitive is well controlled. (1-C, 3/4)
耳鼻咽喉科臨床学会の論文