頭頚部癌に対する弗化ピリミジン系代謝拮抗剤の投与と5Fu有効濃度について

概要

論文の詳細を見る
The concentrations of 5-Fu in the tumor tissue and the serum were measured in 70 patients with head and neck tumors. They consisted of 26 patients treated by regional arterial infusion, 8 by one shot intra-venous injection of 250mg of 5-Fu, 16 by per oral administration of FT207 and 20 by FT207 suppository. The method used was a chemical assay using HPLC. The effective concentration of 5-Fu and clinical curability were discussed.The concentration of 5-Fu in the blood was 1/7 of the level in the tissue in the case of regional arterial infusion therapy, but the former was 2 times of the latter in the case of general administration such as oral, intra-venous and suppository administration.It is recommended that the concentration of 5-Fu in the blood is monitored during therapy. The minimum effective concentration of more than 0.1mcg/ml in the blood and 0.05mcg/g in the tissue should be maintained.It was confirmed that regional arterial infusion therapy of 250mg of 5-Fu per day was effective. In the case of intra-venous continuous injection of 5-Fu more than 1000mg per day was needed to maintain an effective concentration level and 2000mg of FT207 per day was also needed to keep an effective concentration level.A drug which releases a high level of 5-Fu in the tissue with little or no side effects is desired.
耳鼻咽喉科臨床学会の論文