Radio-immunological Determination of IgG in Endolymph Obtained from the Endolymphatic Sac of Two Patients with Ménière's Disease and One Control

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概要

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• During endolymphatic sac surgery in two patients with Meniere's disease, very samll amounts of intra-sac endolymph were obtained along with a tiny specimen of the outer wall of the sac.From a deaf patient with temporal bone fracture, the same specimens were obtained during labyrinthectomy.The homogenated sac wall and human serum albumin, were placed in wells, and the γ-counts were compared after a radio-immunological procedure utilizing the endolymph and 125I-anti Human IgG (Goat). A significantly higher concentration of IgG was found in the endolymph of the patients with Meniere's disease than in the control endolymph.Genetic factors, such as autoimmunity, are discussed as a possible cause of endolymphatic hydrops.

• 耳鼻咽喉科臨床学会の論文

著者

• 太田 健

  東北大学医学部物療内科学教室

• 二木 隆

  東北大学医学部耳鼻咽喉科学教室

• 石井 甲介

  東北大学医学部耳鼻咽喉科学教室

• 山根 雅昭

  東北大学医学部耳鼻咽喉科学教室

• 平井 浩一

  東北大学医学部物療内科学教室

関連論文

• Radio-immunological Determination of IgG in Endolymph Obtained from the Endolymphatic Sac of Two Patients with Ménière's Disease and One Control

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