内耳性難聴に対するBTDS(Beston)の使用経験

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Patients who had the main complaints of dysacousis and tinnitus and were diagnosed as possible inner ear deafness were treated with a large dose (150mg. daily) of BTDS (O-Benzoylthiamine disulfide) in tablet form for a long period of time, 28-170 days. This paper reports clinical course of 12 cases in whom auditory examination could be made after the treatment.Among these 12 cases, the drug was remarkably effective in 3 and effective in 2 cases. It was failed in 7 cases but the tinnitus was relieved in 3 of them. In no case side effects were observed.Some of the patients had previously received various other therapies, especially massive administration of vitamin BI preparations other than BTDS. In these patients vasodilators or metabolic stimulants were concurrently given with BTDS. In general BTDS afforded a greater benefits to those having no previous treatment.The onset of hearing improvement was not always clearly observable. There were no cases, in which immediate effect was seen but some improvement or other was obtained in 2 or 3 weeks. During the long-term treatment with BTDS, the improvement of hearing acuity was seen not always progressively but the period of follow-up examination for half a month to 30 months, there were no worsened cases.
耳鼻咽喉科臨床学会の論文