STUDIES ON THIAMINE DISULFIDE:IV. MICROBIOLOGICAL ACTIVITIES OF O-BENZOYLTHIAMINE DISULFIDE DERIVATIVES

概要

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The activities of thiamine disulfide (TDS) and its derivatives on the growth of Lactobacillus fermenti 36 and of Lactobacillus viridescens S38A were was investigated under various conditions. The activities of TDS and its cetylsulfate (TDS-CS) to both the organisms in the medium without cysteine or cystine were lower than that of thiamine hydrochloride. Under the same conditions, O-propionylthiamine disulfide, O-acetyl-, O-furoyl- and O-benzoylthiamine disulfides showed only a slight activity. However, the activities of TDS and TDS-CS became higher than that of thiamine when the medium contained cysteine or cystine, especially the derivatives were autoclaved with the medium. The other derivatives showed 10-80 per cent activity of thiamine under the same condition.
日本ビタミン学会の論文