STUDIES ON HIGHER ALKYLSULFATES OF THIAMINE

概要

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Comparing the chemical properties and surface activity of thiamine dialkylsulfate with that of sodium alkylsulfate and the absorbability of thiamine dicetylsulfate with that of thiamine hydrochloride after oral administration to rabbits, the following results were obtained.1. When the cation of sodium alkylsulfate is substituted by thiamine, an elevation of about 15° in the Krafft point resulted. Likewise, a remarkable increase in the efficiency of micelle formation and solubilizing power, and also an increase in lipophilic property are observed.2. As the result of measurement of hydrophilic-lipophilic balance values in emulsification test, a marked increase in the lipophilic property and excellent emulsifying power are recognized.3. The absorbability of thiamine by rabbits was indicated by the mean of the total sum of the maximal absorption as, for instance, they were 8.22 and 14.55μg per 100ml in thiamine hydrochloride and thiamine dicetylsulfate respectively.
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