STUDIES ON ANTIVITAMIN B6 ACTIVITY OF TOXOPYRIMIDINE

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概要

• 論文の詳細を見る

• It was proved both by animal experiments and by bacterial growth that TXP showed an antivitamin B6 activity under conditions similar to those employed in the case of 4-desoxypyridoxine, a known antimetabolite of pyridoxine. That is, a typical symptom of vitamin B6 deficiency (acrodynia) was produced in rats with the aid of TXP. It was shown that TXP inhibited the growth action of pyridoxine in vitamin B6-deficient rats, whose body weight had stopped to increase. TXP was found to possess an antivitamin B6 action characterized by the abnormal metabolism of tryptophan. TXP inhibited the growth of S. carlsbergensis (IFO 0565), especially in the culture medium containing thiamine. The relationship between TXP and pyridoxine was competitive in a certain concentration range tested.

• 日本ビタミン学会の論文

著者

• SHINTANI SHIGERU

  Osaka Plant, Takeda Chemical Ind., Ltd.

関連論文

• STUDIES ON FAT-SOLUBLE VITAMIN B6:II. VITAMIN B6 ACTIVITY OF PYRIDOXINE PALMITATES ON THE GROWTH OF SACCHAROMYCES CARLSBERGENSIS AND VITAMIN B6-DEFICIENT RATS
• STUDIES ON ANTIVITAMIN B6 ACTIVITY OF TOXOPYRIMIDINE

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