EFFECT OF THIAMINE TETRAHYDROFURFURYL DISULFIDE UPON THE INTESTINAL MOTILITY

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1. On non-anesthetized dogs provided with the normal, decentralized and aganglionic Thiry-Vella jejunal loops the effect of thiamine tetrahydrofurfuryldisulfide (TTFD) upon the intestinal motility was studied.2. On the normal and decentralized loops the intravenous administration of 1.5mg/kg of TTFD produced a slight rise of tone and a remarkable increase of the amplitude of rhythmic contractions for about 25 minutes.3. In the animal anesthetized with 25mg/kg of pentobarbital sodium the drug also increased the motility of the normal and decentralized loops as remarkably as in the non-anesthetized animal.4. The drug exerted no action upon the aganglionic loop.5. A small amount (1ml) of 5mg/kg TTFD solution which had been carefully introduced into the intestinal lumen, stimulated the mucosa to elicit the mucosal intrinsic reflex the effect of which consisted of an excitation above and inhibition below the stimulated spot.6. The probable site of action of the drug was discussed.
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