Effect of Certain Vitamins on the Formation of Cross-links in the Collagen of Lathyritic Rats

概要

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With a view to study the formation of cross-links in BAPN treated rats by the simultaneous administration of certain vitamins, seven groups of weauling albino rats were raised for three weeks on basal dietalone or vitamin deficient basal diets with BAPN. One of the vitamins namely calcium pantothenate, vitamin E and vitamin B12 was supplemented along with BAPN. The analysis of skins showed that α1-and α2-chains of neutral salt-soluble collagen appreciably increased, β11-and β12-chains and aldehyde content of the neutral salt-soluble collagen significantly decreased, whereas the solubility of insoluble collagen in 2 M/KCNS greatly increased under the influence of BAPN in the vitamin deficient groups. Among the vitamins tested, calcium pantothenate gave the maximum beneficial effect against these lathyragenic changes and vitamin E was the next best.