Effect of Ascorbic Acid on Hydroxylase Activity:I. Stimulation of Tyrosine Hydroxylase and Tryptophan-5-Hydroxylase Activities by Ascorbic Acid
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概要
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The effect of ascorbic acid on the hydroxylase and dehydrogenase activities was studied in vivo to clarify its role in the biological oxidation. Tyrosine hydroxylase and tryptophan-5-hydroxylase which require 2-amino-4-hydroxy-6, 7-dimethyltetrahydropteridine (DMPH4), NADP and molecular oxygen were investigated with the non-scorbutic and scorbutic guinea pigs. Several dehydrogenases such as glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malic enzyme, which require no molecular oxygen but NADP, were also studied by comparing the activities in the non-scorbutic guinea pig with those in the scorbutic guinea pig. The results indicated that the activities of tyrosine hydroxylase and tryptophan-5-hydroxylase of the adrenal gland, liver and brain of the nonscorbutic guinea pig were higher than the values found in the scorbutic guinea pig, although no significant change in the activity of dehydrogenase was observed in the tissues of the non-scorbutic and scorbutic guinea pigs.
- 日本ビタミン学会の論文
著者
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中嶋 洋子
National Institute of Nutrition
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真田 宏夫
National Institute of Nutrition
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河田 正治
National Institute of Nutrition
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鈴江 緑衣郎
National Institute of Nutrition
関連論文
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- EFFECT OF NIACIN DEFICIENCY ON THE METABO-LISM OF BRAIN AMINES IN RATS
- EFFECT OF CATECHOL-THIOL CONJUGATES ON TYROSINASE DEPENDENT TYROSINE HYDROXYLATION
- Effect of nicotinic acid on myelin lipids in brain of developing rat.
- Effect of nicotinic acid on cerebroside synthesis in rat brain.
- UNDERNUTRITION AND BRAIN DEVELOPMENT EFFECT OF LYSINE AND THREONINE SUPPLE-MENTATION ON BRAIN FUNCTION IN MONOZYGOTIC TWINS
- Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig.
- Effect of nicotinic acid on catecholamine synthesis in rat brain.
- Effect of Ascorbic Acid on Hydroxylase Activity:I. Stimulation of Tyrosine Hydroxylase and Tryptophan-5-Hydroxylase Activities by Ascorbic Acid
- Age-related changes in sympathetic nervous activity of rats receiving vitamin E-deficient diet.
- Effect of 3-acetylpyridine on the development of rat brain.
- Influence of nicotinic acid on cerebroside synthesis in the brain of developing rats.
- Effect of 3-acetylpyridine on the content of myelin in the rat brain.