Metabolic Vitamin B Complex Deficiency due to the Administration of Glucocorticoid

スポンサーリンク

概要

• 論文の詳細を見る

• The influence of continuous use of glucocorticoid on the metabolism of vitamin B complex, especially B2, PaA and CoA in young children and rats was investigated. The following results were obtained.1. The observation upon the B2 metabolism in the children receiving continuously large amounts of the hormone shows that the blood B2 content and urinary B2 excretion after loading an adequate amount of FR are higher than in control children not given glucocorticoid. These changes are supposed to be reversible.2. Blood B2 and tissues B1, B2, PaA and CoA contents are increased in the early stage and decreased in the late stage by the continuous use of the hormone in rats. The changes in FAD fraction or CoA content are remarkably distinct compared with other B2 fractions or PaA.3. In adrenalectomized rat liver the total B2 content is slightly decreased, but the FAD fraction is reduced markedly. And also, it is proved that the FAD synthetic activity in adrenalectomized rat liver is definitly interfered with and again, CoA content in such liver is significantly suppressed.4. From these results the possibility for the occurrence of the iatrogenic disturbances in vitamin metabolism by the administration of large amounts of the hormone is suspected.

• 日本ビタミン学会の論文

著者

• 中村 恒男

  Department of Pediatrics, Kyoto Prefectural University of Medicine

• 大矢 紀昭

  Department of Pediatrics, Kyoto Prefectural University of Medicine

• 八木 良造

  Department of Pediatrics, Kyoto Prefectural University of Medicine

• 野本 直記

  Department of Pediatrics, Kyoto Prefectural University of Medicine

関連論文

• Effects of Maternal Hyperphenylalaninemia on Postnatal Myelination in Mice
• Biochemical Studies on the Effect of Maternal Hyperphenylalaninemia on Fetal Brain Maturation of Mice
• Metabolic Vitamin B Complex Deficiency due to the Administration of Glucocorticoid
• CHANGE IN BLOOD LEVEL OF PANTOTHENIC ACID IN CHILDHOOD AND PANTOTHENIC ACID AND COENZYME A CONTENTS IN RAT LIVER WITH GROWTH
• THE EFFECTS OF DIETARY AMINO ACID AND PROTEIN COMPOSITIONS ON COA METABOLISM IN YOUNG ALBINO RATS
• EFFECT OF PANTOTHENIC ACID ADMINISTRATION ON 4′-PHOSPHOPANTETHEINE AND DEPHOSPHO-COA CONTENT IN RAT LIVER DETERMINED BY THE USE OF BIOSYNTHETIC REACTION OF COA IN VITRO FROM THESE PRECURSOR SUBSTANCES
• Studies on the Distribution of Pantothenic Acid, Coenzyme A and their Intermediates in Rat Liver:I. The Isolation and the Identification of Pantothenic Acid, 4′-Phosphopantetheine and Coenzyme A by Using Column and Paper Chromatography
• STUDIES ON THE METABOLISM OF α-LIPOIC ACID IN CHILDHOOD:I. EFFECT OF PROTEIN AND AMINO ACID COMPOSITION IN THE DIET ON THE BIOSYNTHESIS OF PROTEIN-BOUND LIPOIC ACID
• STUDIES ON THE METABOLISM OF α-LIPOIC ACID IN CHILDHOOD:II. URINARY EXCRETION OF α-LIPOIC ACID IN CHILDREN
• STUDIES ON THE METABOLISM OF α-LIPOIC ACID IN CHILDHOOD:III. EFFECT OF DIETARY COMPOSITION AND ANABOLIC STEROID

スポンサーリンク