Effect of Seizure Induced by Hydroxymethylpyrimidine on the Synthesis of Rat Brain Amino Acids from Glucose-U-14C

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概要

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• The free amino acids and glucose of rat brains were determined after separation by high-voltage paper electrophoresis and the isotopic incorporation from glucose-U-14C into the individual amino acids was measured at the preconvulsive stage induced by hydroxy-methylpyrimidine.The absolute level of each amino acid was not so decisively varied, but the incorporation of labeled 14C-glucose into the amino acids was considerably lowered in the drug-treated group.The change of incorporation among each amino acid was relatively constant. It is assumed that the metabolic disturbances of glucose were widely brought about in the drug-treated rats.These changes were not restored by the concomitant administration of pyridoxal-HCI, though the convulsion was completely protected.

• 日本ビタミン学会の論文

著者

• 能勢 善嗣

  Biochemical Institute, Kyoto Prefectural University of Medicine

関連論文

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• PANTOTHENIC ACID AND COENZYME A IN THE ORGANS OF RATS IN PANTOTHENIC ACID DEFICIENCY AND ITS RECOVERY
• Effect of Seizure Induced by Hydroxymethylpyrimidine on the Synthesis of Rat Brain Amino Acids from Glucose-U-14C

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