Cellular Oxidation-Reduction State of Some NAD-linked Reactions in Diabetic Rat Liver, and the Effect of Coenzyme Q Administration
スポンサーリンク
概要
- 論文の詳細を見る
The cytoplasmic reduction-oxidation state of some NAD-linked reactions has been investigated in the liver in vivo under normal and diabetic conditions with or without CoQ7 administration.1. In the liver, the close relationships among lactate/pyruvate, malate/oxaloacetate and glycerol-1-phosphate/dihydroxyacetone phosphate ratios were found in all the metabolic conditions studied. In diabetic rats, these systems were found to be more reduced.2. CoQ7 administration to diabetic rats for four days intramuscularly tended to restore these ratios to normal. This effect was followed by a significant drop in malate concentration.Present findings would indicate that the effect of CoQ7 on the reduced state in diabetic rats seems to be mediated via malate removal.
- 日本ビタミン学会の論文
著者
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繁田 幸男
The First Depertment of Medicine, Osaka University School of Medicine
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泉 寛治
The First Depertment of Medicine, Osaka University School of Medicine
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阿部 裕
The First Depertment of Medicine, Osaka University School of Medicine
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七里 元亮
The First Department of Medicine, Osaka University Medical School
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繁田 幸男
The First Department of Medicine, Osaka University Medical School
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泉 寛治
The First Department of Medicine, Osaka University Medical School
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阿部 裕
The First Department of Medicine, Osaka University Medical School
関連論文
- EFFECT OF COENZYME Q7 TREATMENT ON BLOOD SUGAR AND KETONE BODIES OF DIABETICS
- Cellular Oxidation-Reduction State of Some NAD-linked Reactions in Diabetic Rat Liver, and the Effect of Coenzyme Q Administration
- EFFECT OF PANTETHINE TREATMENT ON VIBRATORY PERCEPTION IN PATIENTS WITH DIABETIC NEUROPATHY