The Clinical and Experimental Studies on the Metabolism of Folic Acid Using Tritiated Folic Acid:II. The Experimental Studies on the Absorption Site and Mechanism of Tritiate Folic Acid in Rats

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概要

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• 1. The site and mechanism of folic acid (FA) absorption were studied in the rat, using 3H-FA.2. After intragastric administration of 40μg of 3H-FA per kg of body weight, 79.3 per cent of the administered dose was absorbed from the upper gastrointestinal tract in 6 hours.3. From the jejunal loop, 91.7 per cent of the injected dose was absorbed in 6 hours, and the absorption from the ileum was about 50 per cent of that from the jejunum.4. With the increase of administered doses, the rate of absorption was decreased, while the absolute amount of the absorbed FA increased almost linearly.5. The absorption of FA was not affected by the following conditions: simultaneous administration of Amethopterin or dinitrophenol, pretreatment with Amethopterin or FA, and deficiency of FA.6. The site and mechanism of FA absorption were discussed and a passive transport for FA was suggested.

• 日本ビタミン学会の論文

著者

• 吉野 俊昭

  The First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

関連論文

• The Clinical and Experimental Studies on the Metabolism of Folic Acid Using Tritiated Folic Acid:III. Plasma Clearance in Man and Organ Distribution in Rat Following Intravenous Administration of Tritiated Folic Acid
• The Clinical and Experimental Studies on the Metabolism of Folic Acid Using Tritiated Folic Acid:I. Absorption Tests of Tritiated Folic Acid in Man
• The Clinical and Experimental Studies on the Metabolism of Folic Acid Using Tritiated Folic Acid:II. The Experimental Studies on the Absorption Site and Mechanism of Tritiate Folic Acid in Rats
• HEMATOLOGIC EFFECT OF 5, 6-DIMETHYL-BENZIMIDAZOLYL COBAMIDE COENZYME IN A PATIENT WITH PERNICIOUS ANEMIA

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