脊椎動物における睾丸組織内脂質顆粒の移動と量的変化の研究
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Comparative studies on the migration and the quantitative changes of the lipid granules in testicular tissues accompanying the spermatogenetic wave were made in different classes of vertebrates and yielded the following results. The materials used in eluded the cattle, hogs, dogs, guinea pigs, rats, mice, the domestic fowl, <I>Takydromus takydromoides</I> (a lizard), <I>Ranacastebiana</I>and<I>Cyprinus auratus</I> (a fish).<BR>(1) The migration of the lipid granules in testicular tissues which accompanies the spermatogenesis is recognized in all the vertebrates investigated. In the mammals and tne domestic fowl, changes in their quantity are also marked besides the migration. On the basis of both these phenomena, five characteristic stages are distinguishable.<BR>(2) In the cattle, hogs, rabbits and the domestic fowl, tne lipid granules in the basal part of SERTOLI cells persist through all the stages of the spermatogenesis, but in the dogs, guinea pigs, rats and mice, they disappear at the stage where the sperms become free in the lumen. In hogs, dogs, rats and mice, tne large lipid granules about 5μ to 10μ in diameter are found, which are believed to represent the reserve lipid. The large lipid granules do not exist in the cattle, rabbits, guinea pigs and the domestic fowl, but the small lipid granules about 10μ in diameter are distributed broadly in SERTOLI cells.<BR>This is related closely with the extent of development of the interstitial tissue and the differ difference in the integrity of the basement membrane.<BR>(3) That quantity of the lipid granules, which are found in seminiferous tubules seems to vary in different animals. This may be attributable to a difference either in the ability or in the mode of sperm production.<BR>(4) In the land vertebrates, the lipid granules on the distal end of the SERTOLI cell get into the lumen at the same time as the sperms are freed therein, whereas in the<I>Cyprinus auratus</I>they remain within the confines of that cell through all the stages of tne spermatogenesis and are never sloughed into the lumen. The lipid in the seminiferous tubules of the latter resembles neutral fat in character and seems to prosses an additional function of protecting the spermhtogenetic cells.<BR>(5) In rats, it has been confirmed by observations on the serial sections of an isolated semi niferous tubule that about six tenths of one spermatogenetic wave represent the stage where the sperms are completely formed and freed into the lumen and the lipid granules in number and disappear eventually.<BR>This time interval, during which the spermato getic cells mature and complete the formatioi of the sperms, is believed to be of importanc also to the physiology of metabolism of thes cells.<BR>(6) The migration and the quantitative change of the lipid granules in SERTOLI cells, which accompany the spermatogenesis indicate evidently active physiological activity on the part of SERTOLI cells. The lipid may be considered to be expended eventually as energy source for maturation of the spermatogetic cells and the formation of the sperms.
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