GASTROFIBERSCOPIC DIAGNOSIS WITH ACRIDINE ORANGE FLUORESCENCE
スポンサーリンク
概要
- 論文の詳細を見る
In order to determine the cancer involved area accurately which is hard to marginate only by simple endoscopic observation, and to detect plain early gastric cancer (IIb), an attempt was made to establish an endoscopical method with fluorescent color observation of acridine-orange (AO). The most effective way in spraying method was to wash the stomach surface by spraying of 5% NaHCO<SUB>3</SUB> prior to the spray of 0.025% AO, and the resultant fluorescent was observed 30 minutes later. For oral administration method of AO, 500mg of AO was administered 5 hrs. prior to the examination, and the fluorescence was observed endoscopically right after washing the stomach by the NaHCO<SUB>3</SUB> spray. Observed fluorescent colors were greenish yellow (5600Å), yellowish green (5660Å), yellow (5700Å), orange (5880Å), and red (6070Å). By histological confirmation, 24 out of 25 biopsic specimens from the yellow area were proved to be malignant, heref ore the yellow area can be regarded as malignant almostly unexceptionally. No cancer tissue was obtained from yellowish green area. An intriguing fluorescent pattern was observed in depressed type of gastric cancer. The central red area was mostly proved to be cancer and the marginal yellow zone, by which the border of cancer was indicated, was again surrounded by yellowish green. In some cases of Borrmann II, a red color belt was observed between the marginal yellow zone and the outside yellowish green area. Cancer tissue was not proved on the surface of this red color belt, but the submucosal infiltration was observed under the red belt mucosa. The border of the exposed cancer tissue was indicated by the yellow. Thus a great advantage of the endoscopic method with AO was emphasized not only in the diagnosis of cancer involved area, but also detection of IIb and unexposed cancer infiltration.
- 社団法人 日本消化器内視鏡学会の論文