Effects of Glucocorticoid on Fine structure of Skeletal Muscles

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The fine structure of the skeletal muscle from the rabbit given glucocorticoid were studied. Predonisolone was injected in doses of 10mg per kg into the back muscles of the experimental rabbits once daily. Hormone injection periods lasted for a week to four weeks. Gastrocnemius and iliopsoas muscles were prepared for the examinations. The degenerative changes were found microscopically to be localized in a small number of muscular fibers in the rabbits injected for three weeks to four weeks. Electron microscope showed the extensive and distinct involvement of mitochondria and myofibrill. Mitochondria lying in sarcoplasma were enlarged and bizarre, and decreased in number. In the area of the progressive mitochondrial degenerations, the myofibrillar breakdown and the irregularity of Z line of single sarcomere were found. Sarcoplasmic space became distented to several times their normal size, that might be caused by the presence of edema fluid. EMG findings in the treated rabbits indecated the low potentials and no neurogenic patterns.
西日本整形・災害外科学会の論文