Quantiative Observation of Acid Mucopolysaccharides in Synovial Fluids of the knees

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We quantified Acid Mucopolysaccharides (A. M. P.) in synovial fluids of human knees and bovine foreleg and examined the relation between A. M. P. and joint diseases. The materials were aspirated from knee joints of arthritis. Total No. 82. Rheumatoid Arthritis. (R. A.) -35. Osteoarthritis. (O. A.) -26. Other diseases. -21.They were experimented with Kushida-Kira method. (J. Jap. Orthop. Ass. 41. 1. 1967).Results.; From all synovial fluids, Hyaluronic Acid (H. A.) and Chondroitin Sulfate (Ch. S.) were separated by electrophoresis and paper chromatography.We classified these joint diseases to three groups and observed the relation between A. M. P, of each groups and age, pH, and amount of synovial fluids.(1) H. A. tends to decrease with aging but has no relation with pH and volume in R. A. and O. A. In the other, it decreases with increase of volume but has no relation with aging and pH.(2) Ch. S. tends to decrease with aging in R. A. and increase in O. A. but has no relation in the other. It has no relation with pH in three groups and with volume in R. A. and O. A. But in the other, it increases in proportion to volume.Average values of A. M. P. are most in the other, next R. A. and last O. A.In each groups, 2: 1 is most at the ratio of Ch. S./H. A.R. A. was classified to stage (by Steinbrocker) and class (by A. R. A.). The average values of both H. A. and Ch. S. decrease with advance of stage and class.
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