Clinical Studies of Hypothyroid Dwarfism
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The present report offers the result of our studies on various clinical observations and the effect of treatments about 23 cases diagnosed as hypothyroid dwarfism, including 5 cases of acquired hypothyroidism. Endocrine function test; In each of the cases of hypothyroid dwarfism, there is a tendency of serum cholesterol to increase and for protein-bound iodine to decrease. The 131I uptake level is lower than control in many cases, while that of primary hypothyroid dwarfism remarkably goes dawn with no respons to T. S. H-test. Through the electroencephalography, the blood sugger test, the water test and the insuline test, abnormal signs and hypofunction were found. About pituitary-adrenocortical function, the measurements of urinary 17-KS and 17-OHCS tell us that in hypothyroid dwarfism it is far below normal. Those clinical observations suggest that hypothyroid dwarfism may be influenced by functional hypofunction of pituitary gland.Roentogenograms; The retardation in skeletal growth is found in all cases, but the structure of skeleton is not seen morphologically.In addition to the very slow development in bone age, hypothyroid dwarfism shows punctuated epiphyseal dysgenesis symmetrically on both sides, which is typically noted in the hip. This dysgenesis, which helps us diagnosis of hypothyroidismus, is observed on the patient who has fellen ill before the epiphyseal ossification centers appear.By the fact, we can conclude chronological age of the patient who has fallen ill.Treatments and results; The effect of treatments with thyroid hormone were excellent in relieving hypothyroid dwarfism. The first finding of the effect remarkably appeared in bone age and following to it is weight age and height age but not so much as bone age. Mental development was far bellow normal.The effect of treatments were influenced by the age who has fallen ill (congenital or acquired), degree of hypofunction of thyroid gland, functional hypofunction of pituitary gland, and various divices of the treatments.
- 西日本整形・災害外科学会の論文
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