Studies upon Azotemic Osteodystrophy:With Special Reference to its Histopathologic Findings

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Specimens were the 5th rib from 18 adult cases died in uremia. After dehydration they were embedded in methylmetacrylate and sectioned to the thickness of 60 micra. The microradiographic images and tetrachrome stained sections were both examined. Two main features of this disease have hitherto been reported to be osteomalacia and hyperparathyroidism. The widening of osteoid seam, however, was observed in only one case, while the hyperparathyroidism were the common findings. Besides these findings we found frequently the internal demineralization (inside of bone) which were stained deeply with fuchsin. These areas are neither osteomalacic nor osteocytic osteolysis which is frequently found in primary hyperparathyroidism. The hydroxyapatite density in these undermineralized areas were ranged approximately 0.6-1.2 gram per cubic centimeter. We consider these suppression of mineralization may be due to the dysfunetion of osteoblasts and osteocytes.
西日本整形・災害外科学会の論文